Deakin University
Browse

File(s) not publicly available

In vivo models of mechanical loading

chapter
posted on 2019-01-01, 00:00 authored by B Javaheri, N Bravenboer, A D Bakker, A van der Veen, R L de Souza, Leanne SaxonLeanne Saxon, A A Pitsillides
The skeleton fulfils its mechanical functions through structural organization and material properties of individual bones. It is stated that both cortical and trabecular morphology and mass can be (re)modelled in response to changes in mechanical strains engendered by load-bearing. To address this, animal models that enable the application of specific loads to individual bones have been developed. These are useful in defining how loading modulates (re)modeling and allow examination of the mechanisms that coordinate these events. This chapter describes how to apply mechanical loading to murine bones through points of articulation, which allows changes in endosteal, periosteal as well as trabecular bone to be revealed at multiple hierarchies, by a host of methodologies, including double fluorochrome labeling and computed tomography.

History

Title of book

Bone research protocols

Volume

1914

Series

Methods in Molecular Biology

Chapter number

22

Pagination

369 - 390

Publisher

Springer

Place of publication

Berlin, Germany

ISSN

1064-3745

ISBN-13

9781493989966

Language

eng

Publication classification

B1.1 Book chapter; B Book chapter

Extent

35

Editor/Contributor(s)

A Idris

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC