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Influence of Environmental Variables on In Vitro Performance

chapter
posted on 2023-11-10, 04:39 authored by NT Kirkland, N Birbilis
To date, many in vitro Mg biodegradation tests are not being carried out in a reproducible or clear manner. In many cases, values of important variables (such as pH) are not reported, or are not correctly controlled throughout the experiments; in other cases, values are being used which do not mimic physiological conditions. Typical issues include the use of unphysiological temperatures or alkalised media, as well as set-ups with either unadjusted or uncontrolled pH values, far outside the body’s natural range. In many studies, it is difficult to determine what was and was not controlled—this also makes it difficult to compare studies. The influences and impacts of experimental parameters such as pH, solution composition and temperature are discussed in this chapter. It is shown that it is very difficult to relate results from studies performed under non-physiological conditions to in vivo performance.

History

Chapter number

3

Pagination

39-72

ISSN

2192-1091

eISSN

2192-1105

ISBN-13

9783319021225

Language

eng

Extent

5

Editor/Contributor(s)

Kirkland NT, Birbilis N

Publisher

Springer International Publishing

Place of publication

Berlin, Germany

Title of book

SpringerBriefs in Materials

Series

SpringerBriefs in Materials

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