Microelectrode arrays are a promising tool in the study of electrophysiology of the brain in vitro. Allowing non-invasive recording of electrical signals from neuronal networks, the device is a perfect tool to help scientists to understand brain functioning at the cell level and as a whole system. Despite the large increase of MEA technology in terms of device diversity and use in neurophysiology, biological models in vitro are mostly restrained to mammals. This chapter highlights the advantages to combine insects and MEA technology for future neurophysiological studies, and introduce the possible perspectives of this research.