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Management commentary

chapter
posted on 2023-10-26, 04:19 authored by Michael BerkMichael Berk
It is perhaps prudent to preface any discussion about this diagnostic category by standing back and looking at diagnoses more broadly. In no other branch of medicine does pathophysiology linearly track phenomenology, yet we are limited to phenomenological-based diagnostic boundaries. Biomarkers have shown scant respect for the most commonly used diagnostic categories, and treatments too have minimal diagnostic specificity. The only clear caveat perhaps is lithium, whose profile of efficacy is in the domain of classical bipolar disorder and the cyclical recurrent mood disorders. For the rest, we need to acknowledge that we are parsing the clouds on an overcast day. The counterpoint is that we need to make major clinical and treatment decisions on the basis of a very incomplete evidence base, drawing on the basis of experience, interpretation and bias simultaneously from the bipolar and unipolar literature, without a clear pathophysiological foundation.

History

Chapter number

20

Pagination

219 - 225

ISBN-13

9780000000000.0

Edition

2nd

Language

eng

Publication classification

BN.1 Other book chapter, or book chapter not attributed to Deakin

Copyright notice

2012, Cambridge University Press

Extent

32

Editor/Contributor(s)

G Parker