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Mechanical performance and cell response of pure titanium with ultrafine-grained structure produced by severe plastic deformation

chapter
posted on 2022-11-17, 05:59 authored by Y Estrin, Rimma Lapovok, A E Medvedev, C Kasper, E Ivanova, T C Lowe
In a quest for implant materials with low or zero toxicity, the medical community and materials scientists are turning their attention to pure titanium as an alternative to titanium alloys. The loss of mechanical strength due to the deliberate relinquishment of alloying effects can be compensated for by extreme grain refinement that can be produced by severe plastic deformation (SPD) of Ti. We discuss the effects of SPD processing on the mechanical property profile of Ti, focusing on strength and fatigue properties. Of equal significance are the effects of SPD processing on the biological responses of commercially pure Ti in physiological environments. It is demonstrated that the attachment and proliferation of osteoblast cells and mesenchymal stem cells is promoted by SPD processing. On the flip side, growth of Gram-positive and Gram-negative bacteria is accelerated as well. These effects are discussed and interpreted in terms of the surface characteristics of the SPD-processed Ti.

History

Pagination

419 - 454

ISBN-13

9780128124574

Publication classification

B1.1 Book chapter