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Performance analysis of a field-effect-transistor based aptasensor
Prostate cancer is one of the most diagnosed cancers which leads to a considerable number of deaths due to the lack of early and sensitive detection. This paper presents an aptamer functionalized field effect (FET) based biosensor for the detection of prostate cancer. Prostate specific antigen (PSA) is considered as the biomarker for prostate cancer whose detection is confirmed by attaching aptamers onto the sensor surface. Through the modelling and numerical simulation, the paper aims to evaluate and predict the performance parameters such as sensitivity, settling time, and limit of detection (LOD) of a label-free FET based electronic biosensor. Various sensor parameters such as structure (i.e., geometry), type of the FET (e.g., nanowire FET, spherical FET, ion-selective FET, and magnetic particle) radius of the FET channel and incubation time are optimized and analyzed. In addition, concentration of analyte biomolecules, diffusion coefficients and affinity to the receptor molecules are also investigated to determine the optimize performance parameters.
History
Title of book
Microelectronics, electromagnetics and telecommunicationsVolume
372Series
Lecture notes in electrical engineeringChapter number
73Pagination
767 - 775Publisher
SpringerPlace of publication
Amsterdam, The NetherlandsPublisher DOI
ISSN
1876-1100eISSN
1876-1119ISBN-13
9788132227267Language
engPublication classification
B Book chapter; B1 Book chapterCopyright notice
2016, SpringerExtent
73Editor/Contributor(s)
S Satapathy, N Rao, S Kumar, C Raj, V Rao, G SarmaUsage metrics
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