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Silk powder for regenerative medicine
chapter
posted on 2014-03-01, 00:00 authored by Rangam RajkhowaRangam Rajkhowa, Xungai WangXungai WangTwo approaches are used for silk particle production: bottom up and top down. In the bottom up approach, different liquid-solid phase transfer techniques are adapted to fabricate particles from silk solution. In the top down approach, silk fibres are milled by various means to prepare ultrafine silk particles. Many important properties of particles such as size, geometry, porosity, stability and biodegradability are dependent on the specific methods of particle production. These properties influence drug loading and release, delivery modes, biocompatibility and their clearance from the body. Particle properties also determine biomechanical properties of particle reinforced composite scaffolds. Thus correlation between preparation, characterisation and application of silk particles for a specific biomedical application is critical. Progress made in this direction and challenges ahead are discussed in this chapter. © 2014 Woodhead Publishing Limited. All rights reserved.
History
Title of book
Silk Biomaterials for Tissue Engineering and Regenerative MedicineChapter number
7Pagination
191 - 216Publisher
ElsevierPlace of publication
Amsterdam, The NetherlandsPublisher DOI
ISBN-13
9780857096999Language
engPublication classification
B Book chapter; B1 Book chapterCopyright notice
2014, ElsevierExtent
20Editor/Contributor(s)
S KunduUsage metrics
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Categories
Keywords
MillingParticle size distributionParticlesPowderSilkScience & TechnologyLife Sciences & BiomedicineTechnologyCell & Tissue EngineeringBiotechnology & Applied MicrobiologyMaterials Science, BiomaterialsCell BiologyMaterials ScienceMESENCHYMAL STEM-CELLSSPIDER SILKFIBROIN NANOPARTICLESDRUG-DELIVERYIN-VITROERI SILKENZYME IMMOBILIZATIONPROTEINMICROSPHERESSCAFFOLDSDELIVERYMICROPARTICLESMICROCAPSULESSTABILIZATION