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Silk powder for regenerative medicine

chapter
posted on 01.03.2014, 00:00 authored by Rangam RajkhowaRangam Rajkhowa, Xungai WangXungai Wang
Two approaches are used for silk particle production: bottom up and top down. In the bottom up approach, different liquid-solid phase transfer techniques are adapted to fabricate particles from silk solution. In the top down approach, silk fibres are milled by various means to prepare ultrafine silk particles. Many important properties of particles such as size, geometry, porosity, stability and biodegradability are dependent on the specific methods of particle production. These properties influence drug loading and release, delivery modes, biocompatibility and their clearance from the body. Particle properties also determine biomechanical properties of particle reinforced composite scaffolds. Thus correlation between preparation, characterisation and application of silk particles for a specific biomedical application is critical. Progress made in this direction and challenges ahead are discussed in this chapter. © 2014 Woodhead Publishing Limited. All rights reserved.

History

Title of book

Silk Biomaterials for Tissue Engineering and Regenerative Medicine

Chapter number

7

Pagination

191 - 216

Publisher

Elsevier

Place of publication

Amsterdam, The Netherlands

ISBN-13

9780857096999

Language

eng

Publication classification

B Book chapter; B1 Book chapter

Copyright notice

2014, Elsevier

Extent

20

Editor/Contributor(s)

S Kundu