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Suppressors of cytokine signaling : functions in normal biology and roles in disease
Suppressor of cytokine signaling (SaCS) proteins have been identified as key negative regulators of cytokine and growth factor signaling. Therefore, given the diverse roles played by cytokines and growth factors in development and disease, it is not surprising that the sacs proteins themselves possess equally diverse and important functions, such as the control of hematopoiesis, immune function, growth and placental development. Significantly, more recent studies are increaSingly highlighting the crucial roles played by SOCS proteins in disease, particularly their tumor suppressor and anti-infammatory functions. Collectively, this research has served to confirm the importance of this class of proteins and suggests that therapeutic strategies for modulating SOCS proteins might be relevant for a range of diseases.
History
Title of book
Jak-stat pathway in diseaseSeries
Medical intelligence unit (Unnumbered : 2003)Chapter number
2Pagination
10 - 23Publisher
Landes BiosciencePlace of publication
Austin, Tex.ISBN-13
9781587063152Language
engPublication classification
B1 Book chapterCopyright notice
2009, Landes BioscienceExtent
12Editor/Contributor(s)
A StephanouUsage metrics
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