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Suppressors of cytokine signaling : functions in normal biology and roles in disease

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posted on 2009-01-01, 00:00 authored by Alister WardAlister Ward, A Barry, Lynda O'Sullivan
Suppressor of cytokine signaling (SaCS) proteins have been identified as key negative regulators of cytokine and growth factor signaling. Therefore, given the diverse roles played by cytokines and growth factors in development and disease, it is not surprising that the sacs proteins themselves possess equally diverse and important functions, such as the control of hematopoiesis, immune function, growth and placental development. Significantly, more recent studies are increaSingly highlighting the crucial roles played by SOCS proteins in disease, particularly their tumor suppressor and anti-infammatory functions. Collectively, this research has served to confirm the importance of this class of proteins and suggests that therapeutic strategies for modulating SOCS proteins might be relevant for a range of diseases.

History

Title of book

Jak-stat pathway in disease

Series

Medical intelligence unit (Unnumbered : 2003)

Chapter number

2

Pagination

10 - 23

Publisher

Landes Bioscience

Place of publication

Austin, Tex.

ISBN-13

9781587063152

Language

eng

Publication classification

B1 Book chapter

Copyright notice

2009, Landes Bioscience

Extent

12

Editor/Contributor(s)

A Stephanou

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