Deakin University
Browse

File(s) under permanent embargo

The ecology of cancer

chapter
posted on 2019-01-01, 00:00 authored by Beata UjvariBeata Ujvari, Jay Fitzpatrick, Nynke RavenNynke Raven, Jens Osterkamp, Frederic Thomas
Neoplasia, the disease of multicellular organisms, is not only a major cause of human death worldwide but also affects numerous invertebrate and vertebrate species. Similar to other diseases, cancer is a significant physiological burden on the host and hence not only impacts the individual but also influences interindividual interactions, populations and consequently global ecosystems. Despite this, oncology and other biological sciences such as ecology and evolution have until very recently developed in relative isolation. To overcome this caveat, we draw parallel between invasive species and the metastatic cascade and provide an overview of the ecology of cancer at the scale of the organisms and the ecosystems of malignant cells (both at the micro- and macro-scales). We discuss the drivers of metastatic formations in the tissue environment and investigate how individuals respond to malignant growth and the impact of this response on populations. Finally, we provide potential avenues for applying evolutionary ecology principles to cancer prevention and to the development of novel treatment strategies.

History

Chapter number

12

Pagination

153-174

ISBN-13

9783030058548

Language

eng

Publication classification

B1 Book chapter

Extent

12

Editor/Contributor(s)

Bernicker E

Publisher

Springer

Place of publication

Cham, Switzerland

Title of book

Cancer and Society

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC