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The role and regulation of PGC-1α and PGC-1β in skeletal muscle adaptation

chapter
posted on 01.01.2017, 00:00 authored by Severine LamonSeverine Lamon, Aaron RussellAaron Russell
Members of the peroxisome proliferator-activated receptor gamma (PPARγ) coactivator-1 (PGC-1) family of proteins regulate mitochondrial biogenesis and function in the cell. PGC-1α and PGC-1β are highly expressed in skeletal muscle where they partner with numerous transcription factors to regulate energy metabolism. PGC-1α and PGC-1β not only control muscle oxidative capacity by influencing substrate metabolism and fibre type but also regulate essential cell processes in the muscle including angiogenesis, inflammation and neuromuscular junction formation. Positive adaption to exercise increases the expression of the PGC-1 family members in muscle, while conditions associated with muscle atrophy and perturbed metabolic function are often associated with a reduction in PGC-1 levels.

History

Title of book

The plasticity of skeletal muscle: from molecular mechanism to clinical applications

Chapter number

8

Pagination

179 - 194

Publisher

Springer

Place of publication

Singapore

ISBN-13

9789811032929

Language

eng

Publication classification

B1.1 Book chapter

Copyright notice

2017, Springer Nature Singapore Pte Ltd.

Extent

13

Editor/Contributor(s)

K Sakuma