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A state space based approach in non-linear hemodynamic response modeling with fMRI data
conference contribution
posted on 2010-01-01, 00:00 authored by Imali HettiarachchiImali Hettiarachchi, Pubudu PathiranaPubudu Pathirana, P BrotchieIn this paper we use the modified and integrated version of the balloon model in the analysis of fMRI data. We propose a new state space model realization for this balloon model and represent it with the standard A,B,C and D matrices widely used in system theory. A second order Padé approximation with equal numerator and denominator degree is used for the time delay approximation in the modeling of the cerebral blood flow. The results obtained through numerical solutions showed that the new state space model realization is in close agreement to the actual modified and integrated version of the balloon model. This new system theoretic formulation is likely to open doors to a novel way of analyzing fMRI data with real time robust estimators. With further development and validation, the new model has the potential to devise a generalized measure to make a significant contribution to improve the diagnosis and treatment of clinical scenarios where the brain functioning get altered. Concepts from system theory can readily be used in the analysis of fMRI data and the subsequent synthesis of filters and estimators.
History
Event
Annual International Conference of the IEEE Engineering in Medicine and Biology Society (32nd : 2010 : Buenos Aires, Argentina)Pagination
2391 - 2394Publisher
IEEELocation
Buenos Aires, ArgentinaPlace of publication
Piscataway, N.J.Start date
2010-08-31End date
2010-09-04ISSN
1557-170XISBN-13
9781424441242Language
engPublication classification
E1 Full written paper - refereedCopyright notice
2010, IEEETitle of proceedings
EMBC 2010 : Proceedings of the 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society “Merging Medical Humanism and Technology”Usage metrics
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