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Allergen to allergy: identifying epithelial endocytotic pathways of peanut allergens

conference contribution
posted on 2014-01-01, 00:00 authored by Dwan PriceDwan Price, Leigh AcklandLeigh Ackland, Cenk SuphiogluCenk Suphioglu
Food allergy has continued to rise over the past few decades. The
increasing occurrence of sensitivity to certain foods remains to be identified, and the allergen-epithelial interaction in particular remains elusive. Peanuts in particular are still one of the highest contributors of anaphylaxis after ingestion of a food allergen. Previous findings by our research group observed that peanut allergens were able to cross the Caco-2 cell culture model of the intestinal epithelium. Specifically, the major peanut allergens Ara h 1, Ara h 2 and Ara h 3, as well as Ara h 6. The direction of this research has deepened into identifying the mechanism by which the Caco-2 monolayers uptake peanut allergens, specifically by endocytosis. Here, we aim to further our understanding about the pathway from allergen to allergy.

History

Event

European Academy of Allergy and Clinical Immunology. Annual Congress (2014 : Copenhagen, Denmark)

Volume

69

Issue

s99

Series

Allergy

Pagination

266 - 266

Publisher

Wiley

Location

Copenhagen, Denmark

Place of publication

Chichester, Eng.

Start date

2014-06-07

End date

2014-06-11

ISSN

0105-4538

Language

eng

Notes

Published in Allergy, Special Issue: Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 7–11 June 2014, Copenhagen, Denmark, September 2014, Volume 69, Issue Supplement s99, Pages 1–646

Publication classification

E Conference publication; EN.1 Other conference paper

Copyright notice

2014, The Authors

Title of proceedings

EAACI 2014 : Proceedings of the European Academy of Allergy and Clinical Immunology Congress

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