Timber is a natural material which offers superior mechanical properties in parallel to fiber direction when compared against those in perpendicular to the fibers. Cross-laminated timber (CLT) is made up of layers of structurally graded timber, orthogonally oriented in layers whereby it can sustain loading in both directions. CLT is often used as floor panels, and hence, its performance under out-of-plane loading is of significant interest. Low rolling shear modulus resulting in higher shear flexibility of the cross-layers tend to decrease the effective bending stiffness of CLT sections. Developing hybrid CLT using timbers with higher rolling shear modulus as cross-layers in CLT is considered a viable option to improve its performance under out-of-plane loading. The present study investigates the performance of shear analogy and Timoshenko methods in predicting the deflection of hybrid CLT panels while considering different span-to-depth ratios and various combinations of rolling shear modulus. Numerical models were developed to conduct a parametric study and obtained deflection results were compared against those calculated from the shear analogy method and Timoshenko method. It was observed that for CLT with a small span-to-depth ratio and cross-layers made from material with higher rolling shear modulus, the deflection calculated from the analytical methods deviates from the values obtained from the numerical model.