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Characterization of high fluid strain micro contractions to study the stress on biological fluids

conference contribution
posted on 2008-01-01, 00:00 authored by F Tovar-Lopez, Khashayar Khoshmanesh, M Nasabi, G Rosengarten, A Mitchell
Microfluidics has the potential to enhance the understanding of the biological fluids under strain, due to the laminar nature of the fluid and the possibility to mimic the real conditions. We present advances on charaterization of a microfluidic platform to study high strain rate flows in the transport of biological fluids. These advances are improvements on the reproduction of a  constant extensional strain rate using micro contractions and development of 3D numerical models. The micro geometries have been fabricated in polydimethyl siloxame (PDMS) using standard soft-lithography techniques with a photolithographically patterned mold. A comparison of some microcontractions with different funnel characteristics is presented. The Micro Particle Image Velocimetry technique has been applied to validate the numerical simulations. We demonstrate the use of microfluidics in the reproduction of a large range of controllable extensional strains that can be used in the study of the effect of flow on biological fluids.



Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems. Conference (9th : 2008 : Melbourne, Victoria)


Proceedings of SPIE ; vol. 2720


SPIE: The International Society for Optical Engineering


Melbourne, Victoria

Place of publication

Bellingham, WA

Start date


End date






Publication classification

E1.1 Full written paper - refereed; E Conference publication

Copyright notice

2008, SPIE

Title of proceedings

SPIE 2008 : Progress in biomedical optics and imaging : Proceedings of SPIE Biomedical Applications of Micro- and Nanoengineering IV and Complex Systems conference