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Chemiluminescence as a screening tool for bioactive phytochemicals

conference contribution
posted on 2009-01-01, 00:00 authored by Geoffrey McDermott, Xavier ConlanXavier Conlan, Nicole Stupka, Paul FrancisPaul Francis, Neil BarnettNeil Barnett

The health benefits of antioxidant-rich ‘Mediterranean’ type diets high in grain, olives and red wine are well recognised. Since these foodstuffs consist of a complex matrix of chemical components, to date, the primary challenge lies in prioritising and isolating molecules for a physiologically relevant cell culture assay to assess their human health benefits. Currently, the most common approach requires arduous sample fractionation into smaller ‘crude’ extracts, followed by costly cell culture assays, with the bioactive identified only after a positive response in the cell. The work presented within this poster demonstrates the potential for an acidified potassium permanganate chemiluminescence detector as a much simpler screening tool to identify the best bioactive candidates from a complex sample matrix.

History

Event

IUPAC Congress : Chemistry Solutions (42nd : 2009 : Glasgow, U.K.)

Publisher

International Union of Pure and Applied Chemistry

Location

Glasgow, U.K.

Place of publication

Research Triangle Park, N.C.

Start date

2009-08-02

End date

2009-08-07

Language

eng

Publication classification

E3 Extract of paper

Title of proceedings

42nd IUPAC Congress

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