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Current status of biotechnological production of the cholesterol lowering drug lovastatin and its biomedical applications

conference contribution
posted on 2010-01-01, 00:00 authored by Madan Verma, A Jana, S Kanwar
Lovastatin is a potent hypercholesterolemic drug used for lowering blood cholesterol. It acts by competitively inhibiting the enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase involved in the biosynthesis of cholesterol. It is produced by a variety of filamentous fungi including Penicillium species, Monascus ruber and Aspergillus terreus as a secondary metabolite. Production of lovastatin by biotechnology decreases the production cost compared to costs of chemical synthesis. In recent years, lovastatin has also been reported as a potential therapeutic agent for the treatment of various types of tumors and also play a tremendous role in the regulation of the inflammatory and immune response, coagulation process, bone turnover, neovascularization, vascular tone, and arterial pressure. This review focus on the structure, biosynthesis, biotechnological production and biomedical applications of lovastatin.

History

Event

Biomedical Engineering and Assistive Technologies. Conference (2010 : Jalandhar, India)

Pagination

1 - 6

Publisher

BEATS

Location

Jalandhar, India

Place of publication

Jalandhar, India

Start date

2010-12-17

End date

2010-12-19

Language

eng

Publication classification

E1.1 Full written paper - refereed

Title of proceedings

BEATS 2010 : Proceedings of the 2010 International Conference on Biomedical Engineering and Assistive Technologies, Jalandhar, India

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