Development of a zein-based system for colon specific delivery

© Springer Nature Singapore Pte Ltd. 2018. Zein was investigated in this study as a coating material for colon specific delivery of prednisolone. To strengthen the ability of film layer in the protection of a dosage form, Kollicoat® MAE 100P was investigated together with zein in an appropriate ratio. Interactions between these materials were evaluated by Fourier Transform Infrared spectroscopy (FTIR). Through the simulated gastrointestinal (GI) environment, the coated tablets released drug immediately after passing the intestinal medium. Zein was proved to be a potential coating material for a delayed release of drug to colon. FTIR spectra indicated that zein and Kollicoat® MAE 100P had only physical interactions at different ratios. Various parameters should be critically controlled in the preparation process to achieve the colon drug delivery. This work may contribute to new applications of zein for attempts of pharmaceutical scientists to design oral controlled drug release dosage forms.