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Development of microemulsion containing prednisolone

Version 2 2024-06-04, 11:45
Version 1 2019-06-27, 10:48
conference contribution
posted on 2024-06-04, 11:45 authored by MN Pham, T Vo Van, PHL Tran, TTD Tran
© Springer Nature Singapore Pte Ltd. 2018. Prednisolone, an anti-inflammatory drug with a very slight solubility (0.23 mg/mL at 25 °C), high permeability and short biological half-life (2–4 h) in oral administration was selected as the candidate drug for sustained drug release. The aim of this research is to formulate and evaluate the stable formation of oil-in-water microemulsion for enhancing the solubility of the model drug. Microemulsion containing oleic acid as oil component, Tween 20 and P188 as main surfactant and co-surfactant at different ratios were evaluated. The microemulsion was characterized by stability test, particle size, clarity, conductivity and pH value. A stable system at nano size (11.6 and 12.3 nm) which possibly enhanced drug solubility with no drug aggregation.

History

Volume

63

Pagination

509-513

Location

Vietnam

Start date

2017-01-01

End date

2017-01-01

ISSN

1680-0737

ISBN-13

9789811043604

Publication classification

E2 Full written paper - non-refereed / Abstract reviewed

Title of proceedings

BME 2017: 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6)

Publisher

Springer

Place of publication

Singapore

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