Deakin University
Browse

File(s) under permanent embargo

Discovering the effects of omega-6 fatty acids on allergy using a HEK-Blue cell line

conference contribution
posted on 2014-09-01, 00:00 authored by Nayyar Ahmed, Cenk SuphiogluCenk Suphioglu
In recent times, allergy has become a financial, physical and psychological burden to the society as a whole. Allergic reactions can result in life-threatening situations causing morbidity and high economic cost. Therefore, more effective reagents are needed for allergy treatment. Omega-6 fatty acids have gained attention in allergic studies mainly due to their inflammatory properties. Literature suggests that a causal relationship exists between the intake of omega-6 fatty acids such as DPA and AA and atopic individuals suffering from allergies. In an allergic cascade, cytokines IL-4 and IL-13 bind to IL-4 receptor (IL-4R), which activates the STAT6 phosphorylation pathway leading to gene activation of allergen-specific IgE production by B cells. Consequently, IgE production leads to clinical symptoms of allergy. The overall aim of this study is to characterise DPA and AA and their effects on IgE production.

History

Event

European Academy of Allergy and Clinical Immunology. Annual Congress (2014 : Copenhagen, Denmark)

Volume

69

Issue

s99

Pagination

534 - 534

Publisher

Wiley

Location

Copenhagen, Denmark

Place of publication

London, Eng.

Start date

2014-06-07

End date

2014-06-11

ISSN

0105-4538

Language

eng

Publication classification

E Conference publication; EN.1 Other conference paper

Copyright notice

2014, The Authors

Title of proceedings

EAACI 2014 : Proceedings of the European Academy of Allergy and Clinical Immunology Congress

Usage metrics

    Research Publications

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC