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Fundamentals and applications of Maldi-Tof MS

conference contribution
posted on 2010-01-01, 00:00 authored by A Goyal, Y Jain, Madan Verma, A Jana
MALDI was developed for the ionisation of relatively large polypeptides and proteins but its application has widened to incorporate glycoproteins, oligonucleotides and complex carbohydrates. A great advantage of MALDI TOF MS is that the process of soft-ionisation causes little or no fragmentation of analytes, allowing the molecular ions of analytes to be identified, even within mixtures. MALDI TOF MS analysis is sensitive and very rapid as once the sample has been mixed with a 'matrix' on a MALDI target, a spectrum can be generated within seconds. Hence, the majority of protein and oligonucleotide analysis in the context of high throughput proteomics and genomics is carried out by MALDI TOF mass spectrometry.

History

Event

Biomedical Engineering and Assistive Technologies. Conference (2010 : Jalandhar, India)

Pagination

1 - 4

Publisher

BEATS

Location

Jalandhar, India

Place of publication

Jalandhar, India

Start date

2010-12-17

End date

2010-12-19

Language

eng

Publication classification

E1.1 Full written paper - refereed

Title of proceedings

BEATS 2010 : Proceedings of the 2010 International Conference on Biomedical Engineering and Assistive Technologies, Jalandhar, India

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