Previous research has examined the impact of organizational culture(OC) on the implementation of many information systems. However, there is a lack of overall picture on how OC affects the effectiveness of different information systems differently. Based on the Competing Value Framework, this paper proposes a comprehensive framework to explain how the fit between organizational culture and types of IS results in different types of IS effectiveness. This framework can be used by managers to create a proper organizational culture that is compatible with the use of specific information systems.