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Mass spectrometry-based proteomic data for cancer diagnosis using interval type-2 fuzzy system
conference contribution
posted on 2015-01-01, 00:00 authored by Thanh Thi NguyenThanh Thi Nguyen, Saeid Nahavandi, Abbas KhosraviAbbas Khosravi, Douglas CreightonDouglas CreightonAn interval type-2 fuzzy logic system is introduced for cancer diagnosis using mass spectrometry-based proteomic data. The fuzzy system is incorporated with a feature extraction procedure that combines wavelet transform and Wilcoxon ranking test. The proposed feature extraction generates feature sets that serve as inputs to the type-2 fuzzy classifier. Uncertainty, noise and outliers that are common in the proteomic data motivate the use of type-2 fuzzy system. Tabu search is applied for structure learning of the fuzzy classifier. Experiments are performed using two benchmark proteomic datasets for the prediction of ovarian and pancreatic cancer. The dominance of the suggested feature extraction as well as type-2 fuzzy classifier against their competing methods is showcased through experimental results. The proposed approach therefore is helpful to clinicians and practitioners as it can be implemented as a medical decision support system in practice.
History
Event
IEEE International Conference on Fuzzy Systems (2015 : Istanbul, Turkey)Series
IEEE International Fuzzy Systems Conference ProceedingsPagination
1 - 8Publisher
IEEELocation
Istanbul, TurkeyPlace of publication
Piscataway, N.J.Publisher DOI
Start date
2015-08-02End date
2015-08-05ISSN
1544-5615ISBN-13
9781467374286Language
engPublication classification
E Conference publication; E1 Full written paper - refereedCopyright notice
2015, IEEEEditor/Contributor(s)
A Yazici, N Pal, U Kaymak, T Martin, H Ishibuchi, C Lin, J Sousa, B TutmezTitle of proceedings
UZZ-IEEE 2015: Proceedings of the IEEE International Conference on Fuzzy SystemsUsage metrics
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No categories selectedKeywords
Science & TechnologyTechnologyEngineering, Electrical & ElectronicEngineeringCancer diagnosismass spectrometrywavelet transformWilcoxon testinterval type-2 fuzzy logic systemtabu searchLOGIC SYSTEMSSAMPLE CLASSIFICATIONBIOMARKER DISCOVERYCLINICAL PROTEOMICSSETSDEFUZZIFICATIONREDUCTIONALGORITHMSELECTION
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