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Microfludic maze for studying the role of neuron-glia signalling in neuronal networks

conference contribution
posted on 2015-01-01, 00:00 authored by Y C Yap, T C Dickson, A E King, Rosanne GuijtRosanne Guijt, M C Breadmore
© 15CBMS-0001. To increase our understanding of the role of glia in signalling within the central nervous system, a novel three-compartment co-culturing device was developed. This device consisted of two compartments for the culture of separate neuron populations, with a third compartment facilitating a glial co-culture. The device utilized an array of 10 banks to create a maze-like structures to block axonal growth and synaptic connections between the two neuron populations, while being permissive to glial growth in a fluidically isolated microenvironment. Ongoing investigation utilizing this platform will help to establish whether glial cells can facilitate the communication and potentially the propagation of pathogenic protein between distinct neuronal populations.

History

Pagination

648 - 650

Publisher

Chemical and Biological Microsystems Society

Location

Gyeongju, Korea

Start date

2015-10-25

End date

2015-10-29

ISBN-13

9780979806483

Publication classification

E Conference publication; EN.1 Other conference paper

Title of proceedings

MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

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