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Neural signal analysis by landmark-based spectral clustering with estimated number of clusters
conference contributionposted on 2014-09-03, 00:00 authored by Thanh Thi NguyenThanh Thi Nguyen, Abbas KhosraviAbbas Khosravi, Asim BhattiAsim Bhatti, Douglas CreightonDouglas Creighton, Saeid NahavandiSaeid Nahavandi
Spike sorting plays an important role in analysing electrophysiological data and understanding neural functions. Developing spike sorting methods that are highly accurate and computationally inexpensive is always a challenge in the biomedical engineering practice. This paper proposes an automatic unsupervised spike sorting method using the landmark-based spectral clustering (LSC) method in connection with features extracted by the locality preserving projection (LPP) technique. Gap statistics is employed to evaluate the number of clusters before the LSC can be performed. Experimental results show that LPP spike features are more discriminative than those of the popular wavelet transformation (WT). Accordingly, the proposed method LPP-LSC demonstrates a significant dominance compared to the existing method that is the combination between WT feature extraction and the superparamagnetic clustering. LPP and LSC are both linear algorithms that help reduce computational burden and thus their combination can be applied into realtime spike analysis.