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On-chip disaggregation of primary human cancer cells from solid tumour biopsies for downstream cellular analysis in a microfluidic device
conference contributionposted on 2023-02-03, 03:15 authored by J Woods, S M Hattersley, P T Docker, K Jiang, C E Dyer, J Greenman, Stephen Haswell
An integrated microfluidic device has been developed to disaggregate ex vivo tumour biopsies, liberating primary human cancer cells, which are then separated by asymmetric laminar flow and trapped downstream for subsequent analysis of intracellular and cell-surface markers. This methodology therefore offers the opportunity for fast patient-specific cellular investigations. © 2008 CBMS.