Mobile Health (mHealth) is now emerging with Internet of Things (IoT), Cloud and big data along with the prevalence of smart wearable devices and sensors. There is also the emergence of smart environments such as smart homes, cars, highways, cities, factories and grids. Presently, it is difficult to quickly forecast or prevent urgent health situations in real-time as health data are analyzed offline by a physician. Sensors are expected to be overloaded by demands of providing health data from IoT networks and smart environments. This paper proposes to resolve the problems by introducing an inference system so that life-threatening situations can be prevented in advance based on a short and long term health status prediction. This prediction is inferred from personal health information that is built by big data in Cloud. The inference system can also resolve the problem of data overload in sensor nodes by reducing data volume and frequency to reduce workload in sensor nodes. This paper presents a novel idea of tracking down and predicting a personal health status as well as intelligent functionality of inference in sensor nodes to interface IoT networks