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Relationship between heart rate variability and angiotensinogen gene polymorphism in diabetic and control individuals
conference contribution
posted on 2014-01-01, 00:00 authored by F Marzbanrad, B Hambly, E Ng, M Tamayo, S Matthews, Chandan KarmakarChandan Karmakar, A H Khandoker, M Palaniswami, H F JelinekHeart Rate Variability (HRV) is extensively used to investigate general Autonomic Nervous System (ANS) function and is affected by many factors including age, gender, pathology such as diabetes and genetic polymorphisms. One of these genetic polymorphisms is the Angiotensin Converting Enzyme (ACE) polymorphism corresponding to insertion (I) or deletion (D) of a 287-base pair sequence of DNA in intron 16 of the ACE gene (rs4340). Some studies have addressed the relationship between HRV and D/D, I/D and I/I ACE polymorphism while others combined I/D and I/I ACE groups. In this study HRV is determined for diabetic and control individuals with different ACE polymorphism considering either separate or combined I/D and I/I genotypes. Linear time domain parameters, entropy, low frequency and total power of HRV were found to be significantly different between diabetic and control individuals with combined I/I and I/D ACE polymorphism, while only entropy was different for diabetic and control subjects with D/D ACE genotype. Separate analysis of I/I and I/D genotypes was preferred for a thorough investigation of HRV and ACE polymorphism, as the combined analysis masked some differences in HRV parameters such as Poincaré plot between ACE polymorphisms and diabetes status. Furthermore, a separate analysis demonstrated that most of the significant differences for HRV were between the diabetic group with I/I genotype and I/D and D/D groups.
History
Event
IEEE Engineering in Medicine and Biology Society. Annual International Conference (36th : 2014 : Chicago, Illinois)Volume
2014Pagination
6683 - 6686Publisher
IEEELocation
Chicago, IllinoisPlace of publication
Piscataway, N.J.Publisher DOI
Start date
2014-08-26End date
2014-08-30ISSN
1557-170XLanguage
engPublication classification
E Conference publication; E1.1 Full written paper - refereedCopyright notice
2014, IEEETitle of proceedings
EMBC 2014 : Proceedings of the 36th Annual International Conference of the IEEE Engineering in Medicine and Biology SocietyUsage metrics
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No categories selectedKeywords
AgedAngiotensinogenCase-Control StudiesDiabetes Mellitus, Type 2FemaleGenetic Association StudiesGenotypeHeart RateHumansMaleMiddle AgedPeptidyl-Dipeptidase APolymorphism, GeneticScience & TechnologyTechnologyEngineering, BiomedicalEngineering, Electrical & ElectronicEngineeringCONVERTING-ENZYME GENEMORTALITY
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