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The influence of pharmacological autonomic blockades on multi-scale measures of heart rate variability
conference contribution
posted on 2017-01-01, 00:00 authored by F Marzbanrad, Chandan KarmakarChandan Karmakar, A H Khandoker, M Palaniswami, T Moritani, H F Jelinek© Springer Nature Singapore Pte Ltd. 2018. Multi-scale measures have been used extensively to characterize non-linear dynamics of heart beats. However a physiological interpretation of the exponents associated with various scales of these measures and the role of the sympathetic and parasympathetic activities have not been attempted. In this study three multi-scale measures were compared at different scales in a pharmacological autonomic blockade experiment, starting with a control phase. It was then followed by injection of propranolol causing sympathetic blockade and injection of atropine resulting in the blockade of both sympathetic and parasympathetic pathways. Multiscale Entropy (MSE), Multi Fractal Detrended Fluctuation Analysis (MFDFA) and Renyi Entropy (RE) were compared using a paired test statistics. The measures performed differently depending on the scale factors and RE showed the best results indicating a good discrimination particularly at higher scale exponents. This study provides a basis for understanding the effect of autonomic activity on multi-scale measures with respect to changes in parasympathetic and sympathetic activity.
History
Event
European Medical and Biological and Nordic-Baltic Conference on Biomedical Engineering and Medical Physics. Joint Conference (2017 : Tampere, Finland)Volume
65Pagination
462 - 465Publisher
SpringerLocation
Tampere, FinlandPlace of publication
Berlin, GermanyPublisher DOI
Start date
2017-06-11End date
2017-06-15ISSN
1680-0737ISBN-13
9789811051210Language
engPublication classification
E1 Full written paper - refereedEditor/Contributor(s)
H Eskola, O Väisänen, J Viik, J HyttinenTitle of proceedings
EMBEC 2017 & NBC 2017 : Proceedings of the 2017 Joint conference of the European Medical and Biological and Nordic-Baltic Conference on Biomedical Engineering and Medical PhysicsUsage metrics
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