As game-based learning takes its shape in accordance to the technological progress, alongside with the concept of learning with principles has become a prominent need. In addition, the relationships that occur among the learning content and the environment of an educational game is vaguely discussed in the literature; hence, the concepts are not explicitly described for developing process of educational games. Therefore, this article briefly highlights the proposed multi-domain framework for game developers to effectively model out the game elements while extracting implicit vaguely supported relationships based on game environment domain and learning principle concepts through a systematic literature review. This paper explains on nine (9) implicit relationships in perspective of game environment domain and learning principles. They are validated through qualitative interviews with eight (8) game-based learning experts. Subsequently, the results are interpreted in relevancy with all domains of proposed framework by applying interpretive hermeneutic approach of qualitative study. The findings conclude nine (9) explicit relationships between game environment domain and the learning principles; for game developers to guide them through the development phased of educational games.