1-Methyl-1 H-pyrazole-5-carboxamide derivatives exhibit unexpected acute mammalian toxicity

Preston, S; Garcia-Bustos, J; Hall, L G; Martin, Sheree; Le, T G; Kundu, A; Ghoshal, A; Nguyen, N H; Jiao, Y; Ruan, B; Xue, L; Huang, F; Chang, B C H; Mcgee, Sean; Wells, T N C; Palmer, M J; Jabbar, A; Gasser, R B; Baell, J B

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1-Methyl-1 H-pyrazole-5-carboxamide derivatives exhibit unexpected acute mammalian toxicity

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posted on 2021-01-14, 00:00 authored by S Preston, J Garcia-Bustos, L G Hall, Sheree MartinSheree Martin, T G Le, A Kundu, A Ghoshal, N H Nguyen, Y Jiao, B Ruan, L Xue, F Huang, B C H Chang, Sean McgeeSean Mcgee, T N C Wells, M J Palmer, A Jabbar, R B Gasser, J B Baell

1-Methyl-1 H-pyrazole-5-carboxamide derivatives exhibit unexpected acute mammalian toxicity

History

Journal

Journal of medicinal chemistry

Volume

64

Issue

1

Pagination

840 - 844

Publisher

American Chemical Society

Location

Washington, D.C.

Publisher DOI

https://doi.org/10.1021/acs.jmedchem.0c01793

ISSN

0022-2623

eISSN

1520-4804

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

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Keywords

oxygen assays rodent models inhibition toxicity Science & Technology Life Sciences & Biomedicine Chemistry, Medicinal Pharmacology & Pharmacy HEPG2 CELLS Organic Chemistry

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File(s) under permanent embargo

1-Methyl-1 H-pyrazole-5-carboxamide derivatives exhibit unexpected acute mammalian toxicity

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