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1'-(2-phenyl-ethylene)-ditryptophenaline, a new dimeric diketopiperazine from Aspergillus flavus

journal contribution
posted on 1994-09-01, 00:00 authored by Colin BarrowColin Barrow, D M Sedlock
A new diketopiperazine dimer, 1'-(2-phenyl-ethylene)-ditryptophenaline [1], was isolated together with ditryptophenaline [2] from the fungus Aspergillus flavus. The structure of 1 was determined by analysis of spectroscopic data. In contrast to the structurally related substance-P antagonist WIN 64821 [3], both 1 and 2 are weak substance-P inhibitors, indicating that stereochemistry at the position of dimerization is an important determinant of biological potency for these molecules.

History

Journal

Journal of natural products

Volume

57

Issue

9

Pagination

1239 - 1244

Publisher

American Chemical Society

Location

Washington, D.C.

ISSN

0163-3864

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

[1994, American Chemical Society]