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1'-(2-phenyl-ethylene)-ditryptophenaline, a new dimeric diketopiperazine from Aspergillus flavus
A new diketopiperazine dimer, 1'-(2-phenyl-ethylene)-ditryptophenaline [1], was isolated together with ditryptophenaline [2] from the fungus Aspergillus flavus. The structure of 1 was determined by analysis of spectroscopic data. In contrast to the structurally related substance-P antagonist WIN 64821 [3], both 1 and 2 are weak substance-P inhibitors, indicating that stereochemistry at the position of dimerization is an important determinant of biological potency for these molecules.
History
Journal
Journal of natural productsVolume
57Issue
9Pagination
1239 - 1244Publisher
American Chemical SocietyLocation
Washington, D.C.Publisher DOI
ISSN
0163-3864Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
[1994, American Chemical Society]Usage metrics
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