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4D bioprinting of smart polymers for biomedical applications: recent progress, challenges, and future perspectives
journal contribution
posted on 2022-12-19, 07:00 authored by ZU Arif, MY Khalid, Ali ZolfagharianAli Zolfagharian, M Bodaghi4D bioprinting is the next-generation additive manufacturing-based fabrication platform employed to construct intricate, adaptive, and dynamic soft and hard tissue structures as well as biomedical devices. It is achieved by using stimuli-responsive materials, especially shape memory polymers (SMPs) and hydrogels, which possess desirable biomechanical characteristics. In the last few years, numerous efforts have been made by 4D printing community to develop novel stimuli-responsive polymeric materials by considering their biomedical perspective. This review presents an up-to-date overview of 4D bioprinting technology incorporating bioprinting materials, functionalities of biomaterials as well as the focused approach towards different tissue engineering and regenerative medicine (TERM) applications. It includes bone, cardiac, neural, cartilage, drug delivery systems, and other high-value biomedical devices. This review also addresses current limitations and challenges in 4D bioprinting technology to provide a basis for foreseeable advancements for TERM applications that could be helpful for their successful utilization in clinical settings.
History
Journal
Reactive and Functional PolymersVolume
179Article number
ARTN 105374ISSN
1381-5148eISSN
1873-166XLanguage
EnglishPublication classification
C1 Refereed article in a scholarly journalPublisher
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Keywords
Science & TechnologyPhysical SciencesTechnologyChemistry, AppliedEngineering, ChemicalPolymer ScienceChemistryEngineering4D printingShape memory polymersHydrogelsBiomedical applicationsScaffoldsTissue engineeringSTIMULI-RESPONSIVE MATERIALSSHAPE-MEMORY POLYURETHANE3DTISSUEHYDROGELSCAFFOLDSFABRICATIONCOMPOSITESALLOYSBONEBiotechnologyRegenerative MedicineBioengineeringMaterials Engineering not elsewhere classifiedMacromolecular and Materials Chemistry not elsewhere classifiedChemical Engineering not elsewhere classified
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