573-P: Pre-exercise Whey Protein Ingestion to Mitigate Exercise-Induced Hypoglycemia in Adults with Type 1 Diabetes

Introduction and Objective: Exercise increases hypoglycemia risk in people with T1D. Pre exercise whey protein ingestion, which stimulates glucagon secretion and endogenous glucose production, may be a novel strategy to mitigate hypoglycemia with exercise in T1D. Methods: Three adults with T1D (mean ± SD HbA1c 6.6 ± 0.3%) using MiniMed 780G underwent two bouts of moderate intensity continuous cycling in the afternoon (60min at 50% VO2max). A standard meal was ingested 4 hours prior and a temporary target set 2 hours pre-exercise. In random order water (control) or whey protein (0.5g/kg) was ingested 30min pre-exercise. Results: Protein ingestion resulted in a diminished exercise associated fall in glucose from exercise onset to end of exercise (-9.6 ± 7.5 vs -55.2 ± 31.6 mg/dL, mean ± SD). From exercise onset to 2 hours post exercise, protein vs control resulted in higher mean glucose (118.7 ± 24.5 vs 168.5 ± 34.4 mg/dL, mean ± SD), and more time >180mg/dL (24.3 ± 29.2 vs 1.8 ± 3.1 %, mean ± SD). There were no instances of hypoglycemia. Conclusion: Pre exercise whey protein ingestion mitigates the drop in glucose during exercise in people with T1D, although the optimal timing and dose of protein ingestion pre-exercise may need to be optimized. Disclosure D. Morrison: None. L. Agnoletto: None. C. Schofield: None. D.T. Hennessy: None. D.P. Zaharieva: Research Support; Hemsley Charitable Trust. Speaker's Bureau; Dexcom, Inc. Research Support; Insulet Corporation, International Society for Pediatric and Adolescent Diabetes. Y.W. Kong: None. J. Apostolopoulos: None. J. Ngan: None. C.E. Smart: None. C. Bruce: None. G.M. Kowalski: None. D.N. O'Neal: None. Funding The Leona M. & Harry B. Helmsley Charitable Trust Grant (2311-06395)