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AMPK-mediated transcription in skeletal muscle
Skeletal muscle phenotype plays a critical role in human performance and health, and skeletal muscle oxidative capacity is a key determinant of exercise tolerance. More recently, defective muscle oxidative metabolism has been implicated in a number of conditions associated with the metabolic syndrome, cardiovascular disease and muscle-wasting disorders. AMPK (AMP-activated protein kinase) is a critical regulator of cellular and organismal energy balance. AMPK has also emerged as a key regulator of skeletal muscle oxidative function, including metabolic enzyme expression, mitochondrial biogenesis and angiogenesis. AMPK mediates these processes primarily through alterations in gene expression. The present review examines the role of AMPK in skeletal muscle transcription and provides an overview of the known transcriptional substrates mediating the effects of AMPK on skeletal muscle phenotype.
History
Journal
Clinical scienceVolume
118Issue
8Pagination
507 - 518Publisher
Portland PressLocation
London, EnglandPublisher DOI
ISSN
0143-5221eISSN
1470-8736Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2010, Portland PressUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineMedicine, Research & ExperimentalResearch & Experimental MedicineAMP-activated protein kinase (AMPK)angiogenesisoxidative capacityskeletal muscletranscriptionACTIVATED PROTEIN-KINASEFATTY-ACID OXIDATIONMITOCHONDRIAL BIOGENESISINSULIN-RESISTANCETRANSGENIC MICEGENE-EXPRESSIONGLUCOSE-UPTAKECOACTIVATOR PGC-1UPSTREAM KINASEIN-VITRO
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