Deakin University
Browse
czeczor-appdeficiency-2018.pdf (1.08 MB)

APP deficiency results in resistance to obesity but impairs glucose tolerance upon high fat feeding

Download (1.08 MB)
Version 2 2024-06-03, 18:46
Version 1 2018-05-30, 13:31
journal contribution
posted on 2024-06-03, 18:46 authored by JK Czeczor, AJ Genders, Kathryn Aston-MourneyKathryn Aston-Mourney, Timothy ConnorTimothy Connor, LG Hall, K Hasebe, Megan EllisMegan Ellis, KA De Jong, DC Henstridge, PJ Meikle, MA Febbraio, Ken WalderKen Walder, Sean McgeeSean Mcgee
The amyloid precursor protein (APP) generates a number of peptides when processed through different cleavage mechanisms, including the amyloid beta peptide that is implicated in the development of Alzheimer’s disease. It is well established that APP via its cleaved peptides regulates aspects of neuronal metabolism. Emerging evidence suggests that amyloidogenic processing of APP can lead to altered systemic metabolism, similar to that observed in metabolic disease states. In the present study, we investigated the effect of APP deficiency on obesity-induced alterations in systemic metabolism. Compared with WT littermates, APP-deficient mice were resistant to diet-induced obesity, which was linked to higher energy expenditure and lipid oxidation throughout the dark phase and was associated with increased spontaneous physical activity. Consistent with this lean phenotype, APP-deficient mice fed a high-fat diet (HFD) had normal insulin tolerance. However, despite normal insulin action, these mice were glucose intolerant, similar to WT mice fed a HFD. This was associated with reduced plasma insulin in the early phase of the glucose tolerance test. Analysis of the pancreas showed that APP was required to maintain normal islet and β-cell mass under high fat feeding conditions. These studies show that, in addition to regulating aspects of neuronal metabolism, APP is an important regulator of whole body energy expenditure and glucose homeostasis under high fat feeding conditions.

History

Journal

Journal of Endocrinology

Volume

237

Pagination

311-322

Location

England

Open access

  • Yes

ISSN

0022-0795

eISSN

1479-6805

Language

English

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2018, Society for Endocrinology

Issue

3

Publisher

BIOSCIENTIFICA LTD