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A Decade of Progress Accelerating Malaria Control in Mali: Evidence from the West Africa International Center of Excellence for Malaria Research
journal contribution
posted on 2023-02-10, 02:19 authored by S Doumbia, N Sogoba, M Diakite, M Toure, M Keita, D Konaté, SI Diawara, A Diarra, D Sanogo, F Kane, SAS Diakite, K Traore, SMB Thiam, SF Traoré, I Cisse, J Mihigo, MB Coulibaly, D Dabitao, M Alifrangis, Alyssa BarryAlyssa Barry, GC Müller, JC Beier, JG ShafferABSTRACT.
This article highlights over a decade of signature achievements by the West Africa International Centers for Excellence in Malaria Research (WA-ICEMR) and its partners toward guiding malaria prevention and control strategies. Since 2010, the WA-ICEMR has performed longitudinal studies to monitor and assess malaria control interventions with respect to space-time patterns, vector transmission indicators, and drug resistance markers. These activities were facilitated and supported by the Mali National Malaria Control Program. Research activities included large-scale active and passive surveillance and expanded coverage of universal long-lasting insecticide-treated bed nets and seasonal malaria chemoprevention (SMC). The findings revealed substantial declines in malaria occurrence after the scale-up of control interventions in WA-ICEMR study sites. WA-ICEMR studies showed that SMC using sulfadoxine‐pyrimethamine plus amodiaquine was highly effective in preventing malaria among children under 5 years of age. An alternative SMC regimen (dihydroartemisinin plus piperaquine) was shown to be potentially more effective and provided advantages for acceptability and compliance over the standard SMC regimen. Other findings discussed in this article include higher observed multiplicity of infection rates for malaria in historically high-endemic areas, continued antimalarial drug sensitivity to Plasmodium falciparum, high outdoor malaria transmission rates, and increased insecticide resistance over the past decade. The progress achieved by the WA-ICEMR and its partners highlights the critical need for maintaining current malaria control interventions while developing novel strategies to disrupt malaria transmission. Enhanced evaluation of these strategies through research partnerships is particularly needed in the wake of reported artemisinin resistance in Southeast Asia and East Africa.
History
Journal
American Journal of Tropical Medicine and HygieneVolume
107Pagination
75-83Location
United StatesPublisher DOI
ISSN
0002-9637eISSN
1476-1645Language
EnglishPublication classification
C1 Refereed article in a scholarly journalIssue
4Publisher
AMER SOC TROP MED & HYGIENEUsage metrics
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Science & TechnologyLife Sciences & BiomedicinePublic, Environmental & Occupational HealthTropical MedicineMILLENNIUM VILLAGES PROJECTTRANSMISSIONAmodiaquineAntimalarialsArtemisininsChildChild, PreschoolDrug CombinationsHumansMalariaMalaria, FalciparumMaliPreventionInfectious DiseasesClinical ResearchRare DiseasesVector-Borne Diseases3.2 Interventions to alter physical and biological environmental risks3 Prevention of disease and conditions, and promotion of well-beingInfection3 Good Health and Well BeingMedical and Health Sciences
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