ritacardoso-bloodbasedbio-2017.pdf (1.4 MB)
A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort
journal contribution
posted on 2017-12-01, 00:00 authored by S Pedrini, Veer GuptaVeer Gupta, E Hone, J Doecke, S O'Bryant, I James, A I Bush, C C Rowe, V L Villemagne, D Ames, C L Masters, R N Martins, G Savage, B Wilson, P Bourgeat, J Fripp, S Gibson, H Leroux, S McBride, O Salvado, M Fenech, M Francois, M Barnes, J Baker, K Barnham, S Bellingham, J Bomke, S B Pejoska, R Buckley, L Cheng, S Collins, I Cooke, E Cyarto, D Darby, V Dore, D El-Sheikh, N Faux, C Fowler, K Harrington, A Hill, M Horne, G Jones, A Kamer, N Killeen, H Korrel, F Lamb, N Lautenschlager, K Lennon, Q X Li, Y Y Lim, A Louey, L Macaulay, L Mackintosh, P Maruff, A McIlroy, J Nigro, K Perez, K Pertile, C Restrepo, Barbara Rita Cardoso, A Rembach, B Roberts, J Robertson, R Rumble, T Ryan, J Sach, B Silbert, C Thai, B Trounson, I Volitakis, M Vovos, L Ward, A Watt, R Williams, M Woodward, P Yates, F Y Ugarte, P Zhang, S Bird, B Brown, S Burnham, P Chatterjee, K Cox, S Fernandez, B Fernando, S Gardener, S Laws, F Lim, L Lim, M Tegg, K Lucas, G MartinsAlzheimer's Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid deposition in HC, suggesting that these two biomarkers might be used to detect at risk individuals. Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ϵ4 allele. This suggests that the physiology of some potential biomarkers may be altered in AD due to the APOE ϵ4 allele, a major risk factor for AD. Taken together, these data highlight several potential biomarkers that can be used in a blood-based panel to allow earlier identification of individuals at risk of developing AD and/or early stage AD for which current therapies may be more beneficial.
History
Journal
Scientific reportsVolume
7Article number
14057Pagination
1 - 12Publisher
Nature Publishing GroupLocation
London, Eng.Publisher DOI
Link to full text
eISSN
2045-2322Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, The AuthorsUsage metrics
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No categories selectedKeywords
Alzheimer’s Disease (AD)dementiaextracellular amyloid depositiontau proteinriskScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsPRECLINICAL ALZHEIMERS-DISEASEREMITTING MULTIPLE-SCLEROSISMILD COGNITIVE IMPAIRMENTAUTOIMMUNE INFLAMMATIONFRONTOTEMPORAL DEMENTIACEREBROSPINAL-FLUIDAPOLIPOPROTEIN-ECONTROLLED-TRIALNEUROPEPTIDE-YINTERLEUKIN-12AIBL Research Group
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