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A cetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with b-amyloid peptides

journal contribution
posted on 2003-03-01, 00:00 authored by J Sáez-Valero, L Fodero, A White, Colin BarrowColin Barrow, D Small
The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer’s disease (AD) brain is unknown. In this study we report that amyloid β-peptides (Aβ) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.

History

Journal

Brain Research

Volume

965

Issue

1-2

Pagination

283 - 286

Publisher

Elesvier

Location

Amsterdam, Netherlands

ISSN

0006-8993

eISSN

1872-6240

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2002, Elsevier Science B.V.

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