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A cetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with b-amyloid peptides
journal contributionposted on 2003-03-01, 00:00 authored by J Sáez-Valero, L Fodero, A White, Colin BarrowColin Barrow, D Small
The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer’s disease (AD) brain is unknown. In this study we report that amyloid β-peptides (Aβ) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.