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A cetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with b-amyloid peptides
journal contribution
posted on 2003-03-01, 00:00 authored by J Sáez-Valero, L Fodero, A White, Colin BarrowColin Barrow, D SmallThe cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer’s disease (AD) brain is unknown. In this study we report that amyloid β-peptides (Aβ) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.
History
Journal
Brain ResearchVolume
965Issue
1-2Pagination
283 - 286Publisher
ElesvierLocation
Amsterdam, NetherlandsPublisher DOI
ISSN
0006-8993eISSN
1872-6240Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2002, Elsevier Science B.V.Usage metrics
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