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A divergent hepatitis D-like agent in birds

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journal contribution
posted on 17.12.2018, 00:00 authored by Michelle Wille, Hans J Netter, Margaret Littlejohn, Lilly Yuen, Mang Shi, John-Sebastian Eden, Marcel KlaassenMarcel Klaassen, Edward C Holmes, Aeron C Hurt
Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents.

History

Journal

Viruses

Volume

10

Issue

12

Publisher

MDPI

Location

Basel, Switzerland

eISSN

1999-4915

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2018, The Authors