A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging
Version 2 2024-06-04, 02:35
Version 1 2015-08-26, 14:40
journal contribution
posted on 2024-06-04, 02:35 authored by CL Fleming, TD Ashton, C Nowell, M Devlin, A Natoli, J Schreuders, Fred PfefferFred PfefferFluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify ‘profluorogenic’ substrates for intracellular studies.
History
Journal
Chemical communicationsVolume
51Pagination
7827-7830Location
London, Eng.Open access
- Yes
eISSN
1364-548XLanguage
engPublication classification
C Journal article, C1 Refereed article in a scholarly journalCopyright notice
2015, Royal Society of ChemistryIssue
37Publisher
Royal Society of ChemistryUsage metrics
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No categories selectedKeywords
Cell DeathCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorFluorescent DyesHistone Deacetylase InhibitorsHumansMicroscopy, ConfocalMicroscopy, FluorescenceMolecular StructureStructure-Activity RelationshipCentre for Chemistry and BiotechnologySchool of Life and Environmental Sciences030401 Biologically Active Molecules030503 Organic Chemical Synthesis920102 Cancer and Related Disorders970103 Expanding Knowledge in the Chemical Sciences030302 Nanochemistry and Supramolecular Chemistry
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