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A methodological review of fetal neurosonographic studies: new directions in assessment of neurodevelopmental risk for mental health problems
journal contribution
posted on 2020-07-01, 00:00 authored by S Whittle, M Finn, Keri LittleKeri Little, Craig OlssonCraig OlssonMost mental disorders are now considered to have neurodevelopmental origins, with a growing body of research pointing to neural alterations that predate birth. However, lack of established methods for reliable investigation of fetal brain development has limited research into early neural vulnerability. Using a systematic approach and quantitative evaluation of study methodology, we review neurosonographic studies of fetal brain structure with objective quality measures. A total of 81 studies were identified. High quality studies were identified for measurement of the corpus callosum, cerebellum, vermis, ventricles and frontal cortex, with reference ranges provided to facilitate future clinical research. Fewer and lower quality studies were available for subcortical structures, prompting a need for further research to create reliable reference ranges. Development and adoption of reference ranges for fetal brain structures should facilitate future research in neurosonographic evaluation of fetal brain development and lead to a better understanding of neurodevelopmental risk and resilience processes for mental disorders.
History
Journal
Neuroscience and biobehavioral reviewsVolume
114Pagination
172 - 193Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0149-7634eISSN
1873-7528Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyNeurosonographyUltrasoundFetusNeurodevelopmentPsychiatryRisk factorTRANSVERSE CEREBELLAR DIAMETERLATERAL VENTRICULAR ATRIUMGRAY-MATTER VOLUMECORPUS-CALLOSUM3-DIMENSIONAL SONOGRAPHYREFERENCE RANGESREFERENCE VALUESBRAIN VOLUMEORBITAL MEASUREMENTSPRENATAL ULTRASOUND
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