callaly-anaturalisticstudy-2010.pdf (307.21 kB)
A naturalistic study of treatment outcomes with aripiprazole in young people with first episode psychosis
journal contribution
posted on 2010-08-01, 00:00 authored by Seetal DoddSeetal Dodd, Thomas Callaly, A Thampi, Stephen Mcconnell, P Hantz, D Goodman, K Kohlmann, P Vieira da Silva Magalhaes, Michael BerkMichael BerkObjective: Adequate treatment of a first psychotic episode in young people is a difficult challenge but may be of critical importance for changing the course of psychotic illness. Pharmacotherapy is the standard treatment of psychosis, however there is a paucity of data specific to first-episode psychosis.
Methods: In this study 12 young people who presented with a psychotic episode at a specialised early intervention service were commenced on treatment with aripiprazole. They were assessed at baseline and weeks 4, 6, 24 and 48 using a broad battery of outcome measures. Case notes were also examined.
Results: Data was available for 6 participants at week 48, and of those, one remained on treatment with Aripiprazole at endpoint. Case histories were typified by presentations that included illicit substance use and treatments characterised by several changes in medications. No single treatment choice predominated. Most participants tolerated treatment and showed symptomatic improvement with individualised therapy.
Conclusion: Most participants showed improvement during the treatment period. Aripiprazole was one of many medications used in this study and may have been useful for the treatment of some individuals with first episode psychosis.
Methods: In this study 12 young people who presented with a psychotic episode at a specialised early intervention service were commenced on treatment with aripiprazole. They were assessed at baseline and weeks 4, 6, 24 and 48 using a broad battery of outcome measures. Case notes were also examined.
Results: Data was available for 6 participants at week 48, and of those, one remained on treatment with Aripiprazole at endpoint. Case histories were typified by presentations that included illicit substance use and treatments characterised by several changes in medications. No single treatment choice predominated. Most participants tolerated treatment and showed symptomatic improvement with individualised therapy.
Conclusion: Most participants showed improvement during the treatment period. Aripiprazole was one of many medications used in this study and may have been useful for the treatment of some individuals with first episode psychosis.
History
Journal
Clinical psychopharmacology and neuroscienceVolume
8Issue
2Pagination
105 - 110Publisher
Korean College of NeuropsychopharmacologyLocation
Seoul, KoreaISSN
1738-1088eISSN
2093-4327Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2010, Korean College of NeuropsychopharmacologyUsage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC