File(s) under permanent embargo
A neuropsychological study of prefrontal lobe function in the positive and negative subtypes of schizophrenia.
journal contributionposted on 1997-12-01, 00:00 authored by D T Mattson, Michael BerkMichael Berk, M D Lucas
The symptoms of schizophrenia are frequently divided into positive and negative subtypes. It has been suggested that the negative symptoms are similar to those seen with prefrontal lobe cortical dysfunction. Several neuropsychological investigations of that hypothesis have been carried out, but none have directly compared a negative symptom group with a positive symptom group on the same test battery. In the present study, the Positive and Negative Syndrome Scale (PANSS; Kay, Fiszbein, & Opler, 1987) was used to distinguish two groups of 20 patients with schizophrenia with predominant positive or negative symptoms. A battery of 7 neuropsychological tests considered capable of isolating prefrontal lobe dysfunction was administered. A significant group difference was noted on 6 of the tests; the negative symptom group performed much worse than the positive symptom group. The results of this study support the hypothesis that a relationship exists between the negative symptoms of schizophrenia and prefrontal lobe dysfunction.
JournalThe Journal of Genetic Psychology: Research and Theory on Human Development
Pagination487 - 494
PublisherTaylor & Francis (Routledge)
Publication classificationC1.1 Refereed article in a scholarly journal
Copyright notice1997, Taylor & Francis (Routledge)
Read the peer-reviewed publication
AdolescentAdultAttentionCognition DisordersFemaleHumansMaleMiddle AgedNeuropsychological TestsPrefrontal CortexProblem SolvingSchizophreniaSchizophrenic PsychologyVerbal BehaviorVolitionSocial SciencesPsychology, DevelopmentalPsychologyPsychology, MultidisciplinaryDYSFUNCTIONSYMPTOMSDEFICITSCORTEXPERFORMANCECIRCUITSBEHAVIOR