A randomised, controlled trial of a dietary intervention for adults with major depression (the 'SMILES' trial): study protocol
journal contributionposted on 15.04.2013, 00:00 authored by Adrienne O'Neil, Michael BerkMichael Berk, C Itsiopoulos, D Castle, Rachelle Opie, Josephine Pizzinga, L Brazionis, A Hodge, Cathy Mihalopoulos, Mary Lou Chatterton, Olivia DeanOlivia Dean, Felice JackaFelice Jacka
Despite increased investment in its recognition and treatment, depression remains a substantial health and economic burden worldwide. Current treatment strategies generally focus on biological and psychological pathways, largely neglecting the role of lifestyle. There is emerging evidence to suggest that diet and nutrition play an important role in the risk, and the genesis, of depression. However, there are limited data regarding the therapeutic impact of dietary changes on existing mental illness. Using a randomised controlled trial design, we aim to investigate the efficacy and cost-efficacy of a dietary program for the treatment of Major Depressive Episodes.