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A randomized controlled double blind study of zuclopenthixol acetate compared to haloperidol in acute psychosis

journal contribution
posted on 1998-01-01, 00:00 authored by S Brook, Michael BerkMichael Berk, S Selemani, J Kolloori, I Nzo
This study is a double blind randomized controlled trial comparing zuclopenthixol acetate to haloperidol administered paarenterally initially and followed by oral medication for 28 days in the treatment of acute psychosis. The sample included 44 patients with schizophrenia, schizophreniform disorder and substance-induced psychotic disorder who required acute neuroleptic treatment. The patients were assessed using the Brief Psychiatric Rating Scale (BPRS), Clinical Global Improvement Scale (CGI) and the Simpson Angus Scale (SAS). While patients in both groups improved on all outcome measures, there was no significant differences between the two agents in terms of either efficacy or tolerability.

History

Journal

Human psychopharmacology

Volume

13

Pagination

17-20

Location

New York, N.Y.

ISSN

0885-6222

eISSN

1099-1077

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1998, John Wiley & Sons, Ltd.

Issue

1

Publisher

John Wiley & Sons