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A rapid test for heroin (3,6-Diacetylmorphine) based on two chemiluminescence reactions
journal contribution
posted on 2006-08-01, 00:00 authored by Kent Mitchell Agg, A Craddock, Richard Bos, Paul FrancisPaul Francis, S Lewis, Neil BarnettNeil BarnettA rapid method for screening drug seizure samples for 3,6-diacetylmorphine (heroin), which consists of a simple hydrolysis procedure and flow-injection analysis with two chemiluminescence reagents, is described. Before hydrolysis, 3,6-diacetylmorphine evokes an intense response with a tris(2,2'-bipyridyl)ruthenium(III) reagent (prepared by dissolving the perchlorate salt in acetonitrile), and a relatively weak chemiluminescence response with a second reagent: potassium permanganate in an aqueous acidic polyphosphate solution. However, the permanganate reagent is extremely sensitive toward the hydrolysis products of 3,6-diacetylmorphine (i.e., 6-monoacetylmorphine and morphine). Some compounds commonly found in drug laboratories may cause false positives with tris(2,2'-bipyridyl)ruthenium(III), but do not produce the markedly increased response with the permanganate reagent after the hydrolysis procedure. The combination of these two tests therefore provides an effective presumptive test for the presence of 3,6-diacetylmorphine, which we have verified with 14 samples obtained from a forensic science laboratory.
History
Journal
Journal of forensic sciencesVolume
51Issue
5Pagination
1080 - 1084Publisher
American Society for Testing and MaterialsLocation
West Conshohocken, PaPublisher DOI
ISSN
0022-1198eISSN
1556-4029Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2006, American Society for Testing and MaterialsUsage metrics
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forensic scienceforensic chemistrychemiluminescencedrug screeningpresumptive chemical testspot testheroin6-diacetylmorphinemorphineScience & TechnologyLife Sciences & BiomedicineMedicine, LegalLegal Medicine3,6-diacetylmorphineFLOW-INJECTION ANALYSISACIDIC POTASSIUM-PERMANGANATECAPILLARY-ELECTROPHORESISCODEINETRIS(2,2'-BIPYRIDYL)RUTHENIUM(III)ALKALOIDSREAGENTSYSTEM
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