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A role for LIM kinase in cancer invasion

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Version 2 2024-06-13, 11:21
Version 1 2019-07-19, 12:57
journal contribution
posted on 2024-06-13, 11:21 authored by K Yoshioka, V Foletta, O Bernard, K Itoh
In this study, we show that LIM kinase 1 (LIMK1), a critical regulator of actin dynamics, plays a regulatory role in tumor cell invasion. We found that the level and activity of endogenous LIMK1 is increased in invasive breast and prostate cancer cell lines in comparison with less invasive cells. Overexpression of LIMK1 in MCF-7 and in MDA-MB-231 human breast cancer cell lines increased their motility, whereas the specific ROCK and Rho inhibitors Y-27632 and C3, respectively, attenuated this effect. In addition, inhibition of LIMK1 activity in the MDA-MB-231 cells by expression of dominantnegative LIMK1 resulted in decreased motility and formation of osteolytic bone lesions in an animal model of tumor invasion. This study shows an important role for LIMK1 signaling in invasion of cancer, demonstrating its potential as a therapeutic molecular target to decrease metastasis.

History

Journal

Proceedings of the National Academy of Sciences of the United States of America

Volume

100

Pagination

7247-7252

Location

Washington, D.C.

Open access

  • Yes

ISSN

0027-8424

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2003, The National Academy of Sciences

Issue

12

Publisher

National Academy of Sciences

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