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A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis

journal contribution
posted on 01.08.2006, 00:00 authored by D Mainieri, S Summermatter, J Seydoux, J P Montani, S Rusconi, Aaron RussellAaron Russell, O Boss, A J Buchala, A G Dulloo
An enhanced metabolic efficiency for accelerating the recovery of fat mass (or catch-up fat) is a characteristic feature of body weight regulation after weight loss or growth retardation and is the outcome of an "adipose- specific" suppression of thermogenesis, i.e., a feedback control system in which signals from the depleted adipose tissue fat stores exert a suppressive effect on thermogenesis. Using a previously described rat model of semistarvation-refeeding in which catch-up fat results from suppressed thermogenesis per se, we report here that the gene expression of stearoyl-coenzyme A desaturase 1 (SCD1) is elevated in skeletal muscle after 2 wk of semistarvation and remains elevated in parallel to the phase of suppressed thermogenesis favoring catch-up fat during refeeding. These elevations in the SCD1 transcript are skeletal muscle specific and are associated with elevations in microsomal Δ9 desaturase enzyme activity, in the Δ9 desaturation index, and in the relative content of SCD1-derived monounsaturates in several lipid fractions extracted from skeletal muscle. An elevated skeletal muscle SCD1, by desaturating the products of de novo lipogenesis and diverting them away from mitochondrial oxidation, would inhibit substrate cycling between de novo lipogenesis and lipid oxidation, thereby leading to a state of suppressed thermogenesis that regulates the body's fat stores.

History

Journal

FASEB journal

Volume

20

Issue

10

Pagination

E1157 - E1170

Publisher

Federation of American Societies for Experimental Biology

Location

Bethesda, Md.

ISSN

0892-6638

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2006, FASEB