A study on acute toxicity and solvent capacity of solvate ionic liquids: in vivo using a zebrafish model (Danio rerio)
Version 2 2024-06-03, 10:51Version 2 2024-06-03, 10:51
Version 1 2016-09-07, 08:54Version 1 2016-09-07, 08:54
journal contribution
posted on 2024-06-03, 10:51authored byP Yoganantharajah, DJ Eyckens, JL Pedrina, Luke HendersonLuke Henderson, Y Gibert
Solvate ionic liquids are equimolar solutions of lithium bistrifluoromethylsulfonimide in triglyme (G3TFSA) or tetraglyme (G4TFSA), are a new class of ionic liquids with potential application in a variety of areas such as energy storage in lithium batteries and as a potential alternative to traditional organic solvents. Herein we present the toxicity of G3TFSA and G4TFSA in an in vivo animal model (Danio rerio), and we also present toxicity data for lithium bistrifluoromethylsulfonimide, bmimTFSA, along with tri- and tetra-glyme to give context to the toxicity of the ionic liquids. Moreover we demonstrated that G3TFSA and G4TFSA have similar solvability compared to DMSO to block retinoic acid synthesis during zebrafish embryogenesis using N,N-diethylaminobenzaldehyde (DEAB). The findings show that, when used in this capacity, DEAB has the same biological effect with no difference in off-target toxicity, validating these ionic liquids as potential replacements for DMSO.
History
Journal
New journal of chemistry
Volume
40
Pagination
6599-6603
Location
Cambridge, Eng.
ISSN
1144-0546
eISSN
1369-9261
Language
eng
Publication classification
C Journal article, C1 Refereed article in a scholarly journal
Copyright notice
2016, Royal Society of Chemistry and the Centre national de la Recherche Scientifique