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A study on acute toxicity and solvent capacity of solvate ionic liquids: in vivo using a zebrafish model (Danio rerio)
journal contribution
posted on 2016-08-01, 00:00 authored by Prusoth Yoganantharajah, Daniel Eyckens, Jessie Pedrina, Luke HendersonLuke Henderson, Y GibertSolvate ionic liquids are equimolar solutions of lithium bistrifluoromethylsulfonimide in triglyme (G3TFSA) or tetraglyme (G4TFSA), are a new class of ionic liquids with potential application in a variety of areas such as energy storage in lithium batteries and as a potential alternative to traditional organic solvents. Herein we present the toxicity of G3TFSA and G4TFSA in an in vivo animal model (Danio rerio), and we also present toxicity data for lithium bistrifluoromethylsulfonimide, bmimTFSA, along with tri- and tetra-glyme to give context to the toxicity of the ionic liquids. Moreover we demonstrated that G3TFSA and G4TFSA have similar solvability compared to DMSO to block retinoic acid synthesis during zebrafish embryogenesis using N,N-diethylaminobenzaldehyde (DEAB). The findings show that, when used in this capacity, DEAB has the same biological effect with no difference in off-target toxicity, validating these ionic liquids as potential replacements for DMSO.
History
Journal
New journal of chemistryVolume
40Issue
8Pagination
6599 - 6603Publisher
Royal Society of ChemistryLocation
Cambridge, Eng.Publisher DOI
ISSN
1144-0546eISSN
1369-9261Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2016, Royal Society of Chemistry and the Centre national de la Recherche ScientifiqueUsage metrics
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